84-5239-63　LRPPRC 200ul　525017

特徴

• May play a role in RNA metabolism in both nuclei and mitochondria.
• In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export.
• May bind mature mRNA in the nucleus outer membrane.
• In mitochondria binds to poly(A) mRNA.
• Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits.
• May be involved in transcription regulation.
• Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors.
• Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP.
• Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters.
• Binds single-stranded DNA (By similarity).
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted antibody in TBS, 5% milk, 0.1% Tween20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200Immunofluorescence (IF-IC): 1:100-1:500ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.