84-5221-28　HP1gamma 200ul　524041

特徴

• Seems to be involved in transcriptional silencing in heterochromatin-like complexes.
• Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
• May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR).
• Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
• Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
• Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).
• Applications:Suitable for use in Western Blot, Immunofluorescence/Immunocytochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Immunofluorescence (IF-IC): 1:100-1:500ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.