84-5201-23　FKBP1A 100ul　522998

特徴

• The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.
• The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin.
• It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor.
• It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor.
• In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
• Multiple alternatively spliced variants, encoding the same protein, have been identified.
• The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.