84-5190-47　DYN1, phosphorylated (Ser778) 200ul　522412

特徴

• Dynamins represent one of the subfamilies of GTP-binding proteins.
• These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain.
• Dynamins are associated with microtubules.
• They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts.
• Dynamins bind many proteins that bind actin and other cytoskeletal proteins.
• Dynamins can also self-assemble, a process that stimulates GTPase activity.
• This gene is located on chromosome 9.
• More than sixty highly conserved copies of the 3' region of this gene are found on other chromosomes, particularly chromosomes Y and 15.
• These copies are referred to as DNM1DN duplicons.
• Multiple splice variants exist for this gene but only two alternatively spliced transcripts encoding distinct isoforms have been described completely.
• Applications:Suitable for use in Western Blot and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.