84-5186-22　DDR1, phosphorylated (Tyr513) 100ul　522195

特徴

• Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation.
• Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.
• Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing.
• Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation.
• Required for normal ear morphology and normal hearing (By similarity).
• Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing.
• Also plays a role in tumor cell invasion.
• Phosphorylates PTPN11.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted antibody in TBS, 5% milk, 0.1% Tween20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.