84-5170-41　CEACAM1 200ul　521378

特徴

• This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily.
• Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy- specific glycoproteins, are located within a 1.2Mb cluster on the long arm of chromosome 19.
• Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster.
• The encoded protein was originally described in bile ducts of liver as biliary glycoprotein.
• Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia.
• The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup.
• Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.
• Multiple transcript variants encoding different isoforms have been reported, but the full- length nature of all variants has not been defined.
• Applications:Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and ELISA.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight
• Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.