Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.
CAK activates the cyclinassociated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation.
CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II byserine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts.
Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Its expression and activity are constantthroughout the cell cycle.
Applications:Suitable for use in Western Blot, Immunohistochemistry and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200ELISA (peptide): 1:20,000-1:40,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of total human CCR1.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human CCR1 at N-terminal. Species sequence homology: bovine (80%), equine (90%), sheep (80%)
