84-5136-39　Opioid Receptor 1, mu (MOR1) 100ug　516567

特徴

• Mu Opioid Receptor (MOP), also called Mu-type opioid receptor (MOR-1), is a receptor for natural and synthetic opioids such as beta-endorphin, endomorphin, morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone.
• MOP functions as a class A G-protein coupled receptor (GPCR), but its down-regulation pathways vary with the agonist and may or may not be independent of G-protein coupling.
• Endogenous ligands induce rapid desensitization, endocytosis and recycling, as opposed to synthetic ligands, like morphine, that trigger only low desensitization and endocytosis.
• Hetero-oligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties.
• MOP is expressed in the brain and is involved in neurogenesis.
• MOP is the main physiological target for most clinically important opioid analgesics.
• Applications:Suitable for use in Immunohistochemistry and Western Blot.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry (paraffin): 1:1000-1:4000 detected Mu Opioid Receptor in human cerebellum, mouse hippocampus, mouse midbrain, and rat midbrain tissue
• Western Blot: 0.2ug/ml detected Mu Opioid Receptor in 10ug of SH-SY5Y cell lysate
• Optimal dilutions to be determined by the researcher.
• Control Peptide:SH-SY5Y cell lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.