Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.
Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that serve as anchors and may be involved in the activation-induced translocation of PKC.
RACK7 (receptor for activated C kinase 7), also known as ZMYND8 (zinc finger MYND domain-containing protein 8), PRKCBP1 (protein kinase C (PKC)-binding protein 1) or PRO2893, is a widely expressed protein with predominant expression in pancreas, lung, placenta and brain.
RACK7 contains one bromodomain, one PHD-type zinc finger, one MYND-type zinc finger and one PWWP domain.
Via its C-terminus, RACK7 interacts with PKC ∫ and is believed to play a role in PKC signaling and function as a transcription regulator.
In response to DNA damage, RACK7 is phosphorylated by ATM or ATR.
In addition, multiple isoforms exist for RACK7.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human ZMYND8 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa586-630 of human ZMYND8.
