The autosomal dominant tricho-rhino-phalangeal syndrome type 1 (TRPS1) is a rare disorder clinically characterized by sparse scalp hair, a bulbous nose, protruding ears, a thin upper lip, an elongated philtrum and bone deformities.
The human TRPS1 gene maps to chromosome 8q24 and encodes a GATA-type zinc-finger protein.
TRPS1 binds GATA sequences but does not activate GATA-dependent transcription.
In fact, TRPS1 represses transcriptional activation mediated by other GATA factors.
The noncompetitive mechanism for transcriptional repression depends upon an Ikaros-like C-terminal region.
In mice, mutations in the GATA domain of TRPS1 cause facial abnormalities that parallel TRPS1 symptoms.
TRPS1 is expressed during mouse embryonic development in developing joints, hair follicles, snout, lung, spine and brain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human TRPS1 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa137-181 of human TRPS1.
