The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains.
TRIM68 (tripartite motif-containing protein 68), also known as RNF137 (RING finger protein 137) or SS56, is a 485aa protein that localizes to the perinuclear region of the cytoplasm.
Expressed in a variety of tissues with higher expression in prostate, spleen and fetal liver, TRIM68 associates with androgen receptor (AR) and, via this interaction, enhances the transcriptional activity of AR.
TRIM68 is found in various cancers, including prostate cancer cells, and is thought to be a therapeutic target for the detection and treatment of prostate cancer.
Additionally, TRIM68 is a target of the autoimmune response exhibited in systemic lupus erythematosus (SLE), primary Sjoegren syndrome and HIV-1 infection.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human TRIM68 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa120-170 of human TRIM68.
