The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin fila- ments at the focal adhesion via F-actin binding and cap- ping activities.
Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphory- lated, suggesting a role in signal transduction cascades.
These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways.
Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane.
It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells.
Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human TNS3 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa535-580 of human TNS3.
