84-5133-05　［取扱停止］NTPCR 100ul　505931

特徴

• Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190aa proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP.
• Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency.
• The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.
• There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A.
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs.
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration.
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis.
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.