Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria.
MRP-L39 (mitochondrial ribosomal protein L39), also known as MRP-L5, L39mt or L5mt, is a 338aa mitochondrial protein that exists as a component of the 39S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis.
MRP-L39 exists as two isoforms produced by alternative splicing.
Isoform one of MRP-L39 is ubiquitously expressed while isoform two is specifically expressed in heart.
The gene encoding MRP-L39 maps to chromosome 21, which makes up about 1.5% of the human genome.
Chromosome 21 contains nearly 300 genes and 47 million base pairs.
Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21.
Alzheimer’s disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human MRPL39 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human MRPL39.
