Mitochondria have their own translation machinery for production of 13 proteins that are required for oxidative phosphorylation.
MRP-L10 (39S ribosomal protein L10, mitochondrial), also known as MRPL8, is a 261aa protein that is a component of the large ribosomal subunit of the mitochondria.
MRP-L10 is one of the 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome.
MRP-L10 is deacteylated in a NAD+- dependent manner by SIRT3, which is an event that contributes to the regulation of mitochondrial protein synthesis.
The gene encoding MRP-L10 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1200 genes.
Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human MRPL10 protein.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa215-259 of human MRPL10.
