Voltage-gated K+ channels in the plasma membrane control the repolarization and frequency of action potentials in neurons, muscles and other excitable cells.
KCNQ proteins contain six transmembrane domains and function as tetramers.
KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.
KCNQ5 expression is highest in the brain and muscle.
Out of the three splice variants of KCNQ5, the longest variant, KCNQ5 type III, is the predominant form expressed in skeletal muscle.
The gene encoding human KCNQ5 maps to chromosome 6q13.
Mutations in the gene encoding KCNQ2, but not in the gene encoding KCNQ5, lead to benign familial neonatal convulsions, while mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling.
Mutations in KCNQ4 are implicated in the onset of deafness.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human KCNQ5 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human KCNQ5.
