The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7.
GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival.
GIMAP4 (GTPase IMAP family member 4), also known as IMAP4 (immunity-associated protein 4) and IAN1 (immunityassociated nucleotide 1 protein), is a 329aa protein that contains 5 motifs that are conserved in GTP-binding proteins and a C-terminal coiledcoiled region that may be responsible for protein-protein interactions.
GIMAP4 exhibits intrinsic GTPase activity that is highly dependent on magnesium concentration to bind GDP.
Showing differential regulation during T-helper cell differentiation, GIMAP4 appears to regulate the apoptosis of T cells.
GIMAP4 is specifically expressed in resting T and B lymphocytes and its protein expression is appreciably decreased upon T or B lymphocyte activation.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human GIMAP4 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human GIMAP4.
