Blood group antigen recognition, metastasis and inflammation utilize fucose, a sugar found in glycoproteins and glycolipids.
Fucokinase, also designated L-fucose kinase or FUK, is a 1084aa enzyme that plays a role in the salvage pathway of fucose reutilization.
A member of the GHMP kinase family, Fucokinase exists as two alternative splice variants and catalyzes L-fucose phosphorylation to form beta-L-fucose 1-phosphate.
The gene encoding Fucokinase maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.
The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human FUK protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa9-53 of human FUK.
