FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805aa protein that contains an F-box near its N-terminal, followed by several leucine-rich repeats and a transmembrane domain at the C-terminal.
F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination.
They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination.
Applications:Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1:50-1:100Western Blot: 1:500Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in Tris, pH 7.4, 1% BSA, 0.05% sodium azide, 40% glycerol
Specificity：Recognizes endogenous levels of FBXL18 and does not cross-react with related proteins. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：FC IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to 750aa of human FBXL18 at C-terminal.
