DUS2L (tRNA-dihydrouridine synthase 2-like), also known as URLC8 (upregulated in lung cancer protein 8) or SMM1, is a 493aa member of the DUS protein family.
Localized to cytoplasm and endoplasmic reticulum, DUS2L uses FAD as a cofactor to catalyze the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.
DUS2L contains one DRBM (double-stranded RNA-binding) domain and has been found to interact with ProRS.
DUS2L is upregulated in most lung cancer cells and has weak expression in normal heart, skeletal muscle and placenta.
The gene that encodes DUS2L maps to human chromosome 16q22.1 and murine chromosome 8 D3.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human DUS2L protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa441-485 of human DUS2L.
