Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer.
DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins.
DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells.
DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26.
DPP7 (dipeptidyl-peptidase 7), also known as DPP2, DPPII or QPP (quiescent cell proline dipeptidase), is expressed in quiescent lymphocytes and localizes to lysosomes.
In response to calcium release, DPP7 can be secreted in its active form.
DPP7 exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides.
DPP7 is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human DPP7 protein.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa430-480 of Human DPP7.
