DMGDH (dimethylglycine dehydrogenase), also known as ME2GLYDH or DMGDHD, is an 866aa mitochondrial protein that plays a role in choline catabolism by catalyzing the demethylation of dimethylglycine to form sarcosine.
Existing as a monomer that belongs to the gcvT family, DMGDH utilizes flavin adenine dinucleotide (FAD) and folate as cofactors.
DMGDH is encoded by a gene that maps to human chromosome 5q14.1, defects of which are the cause of DMGDH deficiency (DMGDHD).
Patients with DMGDHD experience muscle fatigue, have a fish-like odor and excrete an elevated level of N,N-dimethylglycine (DMG) in urine.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human DMGDH protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa810-860 of human DMGDH.
