84-5129-85　［取扱停止］DAPK3, phosphorylated (T265) 100ul　505706

特徴

• Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases.
• Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis.
• A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase.
• ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily.
• ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon.
• Overexpression of ZIP kinase induces apoptosis.
• ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities.
• The messenger RNA was ubiquitously expressed in various tissues.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.