Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 superfamily of enzymes.
CYP2D6 is located in the endoplasmic reticulum where it oxidizes substrates such as drugs and environmental chemicals.
CYP2D6 metabolizes more than 25% of current commonly used drugs including antidepressants, antipsychotics, analgesics, beta-adrenergic blocking agents, antiarrythmics, and antiemetics.
The CYP2D6 gene is highly polymorphic in humans, resulting in phenotypes that vary from poor metabolizer to super metabolizer.
A patient's CYP2D6 genotype was shown to be a good predictor of drug response and side effects and is thus used to guide treatments.
Although abundantly expressed in liver, CYP2D6 is also expressed in other organs including brain.
In brain, CYP2D6 and other CYP family members are expressed in a cell-specific, region-specific manner.
CYP2D6 functions as a neuroprotective enzyme that increases with age and is induced by nicotine and alcohol.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human CYP2D6 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa250-300 of human CYP2D6.
