84-5129-67　［取扱停止］CTSL1 100ul　505690

特徴

• The cathepsin family of proteolytic enzymes contains several diverse classes of proteases.
• The cysteine protease class comprises cathepsins B, L, H, K, S and O.
• The aspartyl protease class is composed of cathepsins D and E.
• Cathepsin G is in the serine protease class.
• Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation.
• Cathepsin L (also designated major excreted protein, MEP or CATL) is a member of the peptidase C1 family and has been identified as a protein that is most closely related to cathepsin H.
• Cathepsin L is a lysosomal cysteine proteinase that mediates intracellular protein catabolism for collagen, elastin and alpha-1 protease inhibitor.
• Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor.
• At least two transcript variants encoding the same protein have been found for this gene.
• Transformed mouse fibroblasts stimulated by growth factors or tumor promoters secrete a form of cathepsin L.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.