Changes in synaptic efficacy can mediate crucial processes during learning and memory formation.
Accumulating evidence implicates cell adhesion molecules in activity-dependent synaptic modifications associated with pairedpulse facilitation (PPF), long-term potentiation (LTP) and long-term depression (LTD).
Among the cell adhesion molecules involved in these processes are the contactins.
Contactins are immunoglobulin superfamily members that play a selective role in synaptic plasticity, PPF and LTD, and may regulate cell-cell interactions contributing to synaptic plasticity in conjunction with other synapse targeting molecules, including paranodin and phosphacan.
In addition, contactins are essential components that control expression and distribution of Na+ channels in neurons, junctional attachment at the paranode, and ultimately the physiology of the myelinated nerve.
The human Contactin 1 gene encodes a 1018aa protein.
The human Contactin 3 gene encodes a 646aa plasmacytoma-associated neuronal glycoprotein.
The human Contactin 5 gene encodes a 1100aa neural adhesion molecule.
The human Contactin 6 gene encodes a 1028aa neural adhesion molecule.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human CNTN1 protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human CNTN1.
