CEP55 (centrosomal protein of 55kD), also known as URCC6 (up-regulated in colon cancer 6), is a 464aa protein that localizes to the centrosome during interphase and may be found throughout the cell during mitosis.
Widely expressed with highest expression in testis and lower expression in thymus, bone marrow, placenta, fetal heart, digestive tract and several carcinomas, CEP55 exists as a homodimer that interacts with centrosome components and is involved in mitotic exit and cytokinesis.
Human CEP55 undergoes several phosphorylation events throughout the cell cycle, most of which are necessary for proper CEP55 function.
Mutations or defects in the gene encoding CEP55 result in a failure to exit mitosis and may be associated with tumor progression.
Two isoforms of CEP55 are expressed due to alternative splicing events.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human CEP55 protein.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human CEP55.
