84-5128-63 ［取扱停止］Catenin-beta, phosphorylated (Y670) 50ul 505619
特徴
- Beta-Catenin is a key downstream effector in the Wnt signaling pathway.
- It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis.
- CK1 phosphorylates beta-catenin at Ser45.
- This phosphorylation event primes beta-catenin for subsequent phosphorylation by GSK-3beta.
- GSK-3beta destabilizes Beta-catenin by phosphorylating it at Ser33, Ser37, and Thr41.
- Mutations at these sites result in the stabilization of beta-catenin protein levels and have been found in many tumor cell lines.
- Applications:Suitable for use in Western Blot.
- Other applications not tested.
- Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
- Storage and Stability:May be stored at 4°C for short-term only.
- Aliquot to avoid repeated freezing and thawing.
- Store at -20°C.
- Aliquots are stable for 12 months.
- For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
- Size：50ul
- Host：rabbit
- Source Antibody：human
- Grade：Affinity Purified
- Purity：Purified by immunoaffinity chromatography.
- Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
- Specificity：Recognizes endogenous levels of human Catenin-beta protein only when phosphorylated at Tyr670. Species Crossreactivity: mouse and rat
- Isotype：IgG
- Calc Applications Abbrev：WB
- Calc Crossreactivity：Hu Mo Rt
- Immunogen：Synthetic phosphopeptide corresponding to human CTNNB1 around the phosphorylation site of Tyrosine 670.
- Shelf Life：6months
- Swiss Prot Number：P35222
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