Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity.
ADM is involved in the regulation of fluid and electrolyte homeostasis and the maintenance of cardiovascular functioning, and in hypertensive patients, the level of ADM in plasma is upregulated.
Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage.
ADM has strong natriuretic actions and ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption.
ADM is present both in the periphery and brain, and this peptide can exert central effects such as decreasing food ingestion.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.3, 0.05% sodium azide.
Specificity：Recognizes endogenous levels of human ADM protein. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa116-160 of human ADM.
