84-5126-28　SLC7A5, NT 200ul　502467

特徴

• Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc.
• Involved in cellular amino acid uptake.
• Acts as an amino acid exchanger.
• Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
• Plays a role in neuronal cell proliferation (neurogenesis) in brain.
• Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity.
• Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane.
• May play an important role in high-grade gliomas.
• Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina.
• Acts as the major transporter of tyrosine in fibroblasts.
• Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:25Western Blot: 1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.