It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.
Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.
May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes.
May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus.
May regulate MYB by inhibiting its DNA- binding activity.
Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity.
Involved in regulation of UV radiation-induced apoptosis.
May be involved in hepatitis C virus (HCV) replication and release.
Applications:Suitable for use in Immunofluorescence, Indirect Flow Cytometry, ELISA, Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 1:25Indirect Flow Cytometry: 1:25Western Blot: 1:2000Immunohistochemistry (Paraffin): 1:25Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human Cyclophilin D.
Isotype：IgG
Calc Applications Abbrev：E FC IF IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa336-370 of the human region of human Cyclophilin D. Species sequence homology: mouse, rat.
