84-5122-71　RBMX, ID 200ul　502351

特徴

• RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes.
• Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs.
• Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression.
• When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter.
• Associates with nascent mRNAs transcribed by RNA polymerase II.
• Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection.
• Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2.
• Represses the splicing of MAPT/Tau exon 10.
• Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer.
• Binds non-specifically to pre-mRNAs.
• Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment.
• Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000-1:2000Immunohistochemistry (Paraffin): 1:25Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.