84-5122-52　KISS1, NT 200ul　501919

特徴

• Metastasis suppressor protein in malignant melanomas and in some breast cancers.
• May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization.
• Generates a C-terminal amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54.
• Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis.
• Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast.
• Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts.
• Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself.
• The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.
• The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
• Applications:Suitable for use in ELISA, Western Blot, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:2000Immunohistochemistry (Paraffin): 1:25Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.