84-5120-34　NDEL1, ID 200ul　502095

特徴

• Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome.
• May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome.
• Also positively regulates the activity of the minus-end directed microtubule motor protein dynein.
• May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
• Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome.
• Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate.
• Plays a role, together with DISC1, in the regulation of neurite outgrowth.
• Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1.
• Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.