Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs.
Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.
Involved in the maturation of both CD4+ and CD8+ cells in the thymus.
Important for follicular differentiation and possibly cell fate selection within the follicle.
During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
Represses neuronal and myogenic differentiation.
May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation.
May be involved in mesoderm development, somite formation and neurogenesis.
May enhance HIF1A function by sequestering HIF1AN away from HIF1A.
Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury.
Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human NOTCH1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa2428-2462 of the C-terminal region of human NOTCH1. Species sequence homology: mouse, rat.
