May position the N- terminal of histone H3 for efficient trimethylation at 'Lys-4'.
As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
May regulate osteoblasts differentiation.
Applications:Suitable for use in ELISA, Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A and peptide affinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes human WDR5. Species Crossreactivity: mouse.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Mo
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within aa321-354 of the C-terminal region of human WDR5. Species sequence homology: bovine, rat, drosophila.
