84-5117-37　TRPV6, ID 200ul　502621

特徴

• Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine.
• The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification.
• Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation.
• In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner.
• Heteromeric assembly with TRPV5 seems to modify channel properties.
• TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).
• Applications:Suitable for use in ELISA, Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.