ZNF180 belongs to the krueppel C2H2-type zinc-finger protein family.
It contains 12 C2H2-type zinc fingers and 1 KRAB domain.
ZNF180 may be involved in transcriptional regulation.Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions.
The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc.
Kruppel-related proteins form 1 family of zinc finger proteins.
See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM].