84-5103-87　ZFP36 (Tristetraprolin, Zinc Finger Protein 36, C3H Type, Homolog (Mouse)) 100ul　495988

特徴

• ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors.
• Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release.
• Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression.
• Multiple phosphorylation sites in ZFP36 in mammalian cells were reported.
• ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family.
• Gene expression profiling predicts clinical outcome of prostate cancer.
• Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
• Applications:Suitable for use in Immunohistochemistry, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.