84-5100-89　XIAP (E3 Ubiquitin-protein Ligase XIAP, X-Linked Inhibitor of Apoptosis) 100ul　495693

特徴

• This gene encodes a protein that belongs to a family of apoptotic suppressor proteins.
• Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function.
• This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme.
• This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
• Mutations in this gene are the cause of X-linked lymphoproliferative syndrome.
• Alternate splicing results in multiple transcript variants.
• Pseudogenes of this gene are found on chromosomes 2 and 11.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.