84-5095-93　UPF1 (Regulator of Nonsense Transcripts 1, UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) 100ul　495202

特徴

• UPF1 is a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
• mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
• When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
• UPF1 is located only in the cytoplasm.
• When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
• Use of multiple polyadenylation sites has been noted for this gene.This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance.
• mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD).
• When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons.
• This protein is located only in the cytoplasm.
• When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
• Use of multiple polyadenylation sites has been noted for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.