84-5094-37　UBE3A (Ubiquitin-Protein Ligase E3A) 100ul　495047

特徴

• UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system.
• This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues.
• Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies.
• The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system.
• This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues.
• Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies.
• The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.
• Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini.
• Additional transcript variants have been described, but their full length nature has not been determined.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.