This gene encodes a member of the family of pyridine nucleotide oxidoreductases.
This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress.
The functional enzyme is thought to be a homodimer which uses FAD as a cofactor.
Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity.
The selenocysteine is encoded by the UGA codon that normally signals translation termination.
The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Alternative splicing results in several transcript variants encoding the same or different isoforms.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human TXNRD1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the middle region of human TXNRD1
