84-5086-13　TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily Member 1A) 100ul　494231

特徴

• TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha.
• The adapter molecule FADD recruits caspase-8 to the activated receptor.
• The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
• TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily.
• This protein is one of the major receptors for the tumor necrosis factor-alpha.
• This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation.
• Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.
• Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome.
• The impaired receptor clearance is thought to be a mechanism of the disease.
• Applications:Suitable for use in Immunofluorescence, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.