TFAP2B belongs to the AP-2 family which is developmentally regulated and have distinct overlapping functions in the regulation of many genes governing growth and differentiation.
TFAP2B binds DNA as a dimmer and can form homodimers or heterodimers with other AP-2 family members.
It may be a candidate for conferring susceptibility to type 2 didabetes.
This gene encodes a member of the AP-2 family of transcription factors.
AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences.
They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development.
Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters.
This protein functions as both a transcriptional activator and repressor.
Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 2% sucrose, 0.09% sodium azide.
Specificity：Recognizes human TFAP2B.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the N-terminal region of human TFAP2B
