TFAP2B belongs to the AP-2 family which is developmentally regulated and have distinct overlapping functions in the regulation of many genes governing growth and differentiation.
TFAP2B binds DNA as a dimmer and can form homodimers or heterodimers with other AP-2 family members.
It may be a candidate for conferring susceptibility to type 2 didabetes.This gene encodes a member of the AP-2 family of transcription factors.
AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences.
They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development.
Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters.
This protein functions as both a transcriptional activator and repressor.
Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
