84-5072-59　SSRP1 (FACT Complex Subunit SSRP1, Structure Specific Recognition Protein 1) 100ul　492891

特徴

• SSRP1 is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT.
• FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation.
• FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin.
• SSRP1 contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA.
• It also functions as a co-activator of the transcriptional activator p63.The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT.
• FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation.
• FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin.
• This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA.
• This protein also functions as a co-activator of the transcriptional activator p63.
• An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.