84-5071-69　SREBF1 (Sterol Regulatory Element-Binding Protein 1, Sterol Regulatory Element Binding Transcription Factor 1) 100ul　492802

特徴

• SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis.
• The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum.
• Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1.
• Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription.
• The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis.
• The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum.
• Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1.
• Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription.
• The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
• This gene is located within the Smith-Magenis syndrome region on chromosome 17.
• Two transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.