84-5069-88　SPANXB1 (Sperm Protein Associated with the Nucleus on the X Chromosome B/F) 100ul　492623

特徴

• Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa.
• This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X.
• The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments.
• This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus.
• The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members.
• Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa.
• This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.