84-5065-60　SLC8A1 (Sodium/Calcium Exchanger 1, Solute Carrier Family 8 (Sodium/Calcium Exchanger), Member 1) 100ul　492199

特徴

• In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation.
• The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores.
• However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane).
• During relaxation, Ca(2+) is sequestered within the intracellular stores.
• To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell.
• The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation.
• In the heart, the exchanger may play a key role in digitalis action.
• The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.